Evaluation of the effects of Krill Oil on the Clinical Course of Hyperlipidemia

JSS medical research inc. June 7, 2003

 

Abstract

Krill Oil was tested on a group 120 patients with mild to high hyperlipidemia (high cholesterol). In a multi-clinical, 3-month, prospective, randomized study, the patients were randomly assigned to 4 groups: Krill Oil 2-3 gm/day (based on BMI), 1.5-1.0 gm/day (based on BMI), an active control group taking 3.0 gm/day fish oil, and a placebo group.

Primary parameters tested were: total cholesterol, triglycerides, HDL and LDL cholesterol, and Cholesterol/HDL ratio.

The results of the present study demonstrate within high levels of confidence that:

1. KO is effective for the management of hyperlipidemia by significantly reducing total cholesterol, LDL and triglycerides and increasing HDL levels.

2. KO 1.5 gr/day is more effective than Fish Oil 3.0 gr/day for the management of hyperlipidemia by significantly reducing LDL levels.

3. At equal doses, KO 3.0 gr/day is more effective than Fish Oil 3.0 gr/day for the management of hyperlipidemia by significantly reducing triglycerides and LDL levels.

 

 

 

STATISTICAL RATIONALE AND ANALYSIS:

A sample size of 120 patients (30 patients/group) will provide 90 % power to detect a 15% change in total cholesterol from baseline to 3 months.

Within group differences reflecting changes over time for the same patient were assessed for statistical significance with the Paired Student’s t-test. Between group differences were assessed with planned comparisons of one way analysis of variance.

 

MAIN STUDY GROUP ANALYSIS

BMI DEPENDENT KO SUBGROUP ANALYSIS

GROUP C1 : 2 g KO – Subgroup of C (15 patients)
	0 days	90 days	% Change
	mmol/l
Total Cholesterol	6.40	5.24	-18.13%
LDL	4.73	2.96	-37.42%
HDL	1.32	2.05	55.30%
Triglycerides	1.81	1.31	-27.62%

 

 

GROUP D1 :– Subgroup of D (17 patients) -
1.0 g KO (0		– 90 days)		0.5 g KO (91 – 180 days)
	0 days	90 days	% Change	91 - 180 days	% Change
	mmol/l			mmol/l
Total Cholesterol	6.10 5.28		-13.44%	4.92	-19.34%
LDL	4.34 2.95		-32.03%	2.93	-32.49%
HDL	1.48 2.13		43.92%	1.96	32.43%
Triglycerides	1.36 1.21		-11.03%	1.6	17.65%
GROUP D2 :– Subgroup of D (13 patients) -
1.5 g NKO (0		– 90 days)		0.5 g NKO (91 – 180 days)
	0 days	90 days	% Change	90 - 180 days	% Change
		mmol/l		mmol/l
Total Cholesterol	5.98	5.16	-13.71%	4.88	-18.39%
LDL	4.26	2.74	-35.70%	2.85	-33.10%
HDL	1.52	2.17	42.76%	2.01	32.24%
Triglycerides	1.43	1.26	-11.89%	1	-30.07%

 

4. KO 1.0 - 1.5 gr/day (BMI dependent) is significantly more effective than Fish Oil 3.0 gr/day for the reduction of:

a. Glucose

b. Low Density Lipoprotein (LDL)

5. KO 2.0 - 3.0 gr/day (BMI dependent) is significantly more effective than Fish Oil 3.0 gr/day for the reduction of:

a. Glucose

b. Triglycerides

c. Low Density Lipoprotein (LDL)

6. KO at a maintenance dose of 0.5 gr/day is significantly effective for maintenance within normal ranges of:

a. Glucose

b. Total cholesterol

c. Triglycerides

d. Low Density Lipoprotein (LDL)

e. Cholesterol : HDL ratio

f. High Density Lipoprotein (HDL)

Recommended Dosage:

According to the results of the present study the recommended dose of KO for the management of blood lipids and glucose within normal levels is 1.0­1.5g/day (BMI dependent) for 30 days (booster dose) and continuing with a maintenance dose of 0.5g/day.

Conclusion

The results of the present study demonstrate within high levels of confidence that:

1. NKO^™ is effective for the management of hyperlipidemia by significantly reducing total cholesterol, LDL and triglycerides and increasing HDL levels.

2. NKO^™ 1.5 gr/day is more effective than Fish Oil 3.0 gr/day for the management of hyperlipidemia by significantly reducing LDL levels.

3. At equal doses, NKO^™ 3.0 gr/day is more effective than Fish Oil 3.0 gr/day for the management of hyperlipidemia by significantly reducing triglycerides and LDL levels.

 

 

Key concepts: Neptune Krill Oil, EPA, DHA, blood lipid lowering, cholesterol, triglycerides, LDL, HDL