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Health News and ResearchMeta-analysis of Coenzyme Q10 in physical exercise, hypertension and heart failureCoenzyme Q10 in Physical ExerciseWe identified eleven studies in which CoQ10 was tested for an effect on exercise capacity, six showed a modest improvement in exercise capacity with CoQ10 supplementation but five showed no effect. CoQ10 in HypertensionWe identified eight published trials of CoQ10 in hypertension. Altogether in the eight studies the mean decrease in systolic blood pressure was 16 mm Hg and in diastolic blood pressure, 10 mm Hg. Being devoid of significant side effects CoQ10 may have a role as an adjunct or alternative to conventional agents in the treatment of hypertension. CoQ10 in Heart FailureWe performed a randomised double-blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Over 3 months, in the CoQ10 patients but not in the placebo patients there were significant improvements in symptom class and a trend towards improvements in exercise time. Meta-Analysis of Randomised Trials of Coenzyme Q10 in Heart FailureIn nine randomised trials of CoQ10 in heart failure published up to 2003 there were non-significant trends towards increased ejection fraction and reduced mortality. There were insufficient numbers of patients for meaningful results. To make more definitive conclusions regarding the effect of CoQ10 in cardiac failure we recommend a prospective, randomised trial with 200-300 patients per study group. Further trials of CoQ10 in physical exercise and in hypertension are recommended. Source:Rosenfeldt F, Hilton D, Pepe S, Krum H. Systematic review of
effect of coenzyme Q10 in physical exercise, hypertension and
heart failure. Biofactors. 2003;18(1-4):91-100.
Key concepts: Coenzyme Q10, CoQ10, physical exercise, hypertension, blood pressure, heart failure |
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