Primary Cellular Energy Considerations
- Promote tissue vascularization, mitochondrial biogenesis and oxidative metabolism
- Increase overall energy production, maximize endurance capacity, enhance cognitive function and promote reduction of oxidative stress and the effects of aging.
- Targeted for cardiovascular health, sexual health, cognitive health
- Support healthy mitochondria and endothelial function
- Gluten, Soy, GMO Free. Vegetarian.
- Formula exclusive to practitioner channel. Current clinical trial for endothelial function. Unique formulation of standardized, branded PQQ, H2Q® CoQ10, Oxystorm®, L-Arginine, and Epicatechin as PhytoSure™, each demonstrating their effectiveness in published studies.
Individual Components in Cellular Optimizer™ proprietary formula:
Oxystorm® (Red Spinach Extract leaves, Amaranthus dubius, Amaranthas tricolor)
Leafy vegetables and roots, specifically red spinach, are rich sources of dietary nitrate. In fact, OXYSTORM’s Standardized Nitrate contains more than five times the amount of nitrate as beetroot powder, and more than 50 times as beet juice. Amaranth (red spinach) is popularly grown in tropical regions of the world including Africa, India, Bangladesh, Sri Lanka, and the Caribbean. It is also grown throughout southeast Asia and Latin America (Subramanian & Gupta, 2015).
Aside from its high concentration of nitrate, amaranth is an excellent source of potassium, carotenoids, iron, calcium, ascorbic acid, and proteins. Furthermore, Subramanian and Gupta (2015) found that a single oral does of amaranth extract can increase the NO3- and NO2- levels in the body for at least 8 hours, improving overall performance of people involved in vigorous physical activity.
Red spinach extract has been shown to increase humoral and plasma nitrate, peak reactive hyperemia calf blood flow, and acute microvascular reactivity of the lower limbs (Haun, et. al., 2016). More specifically, nitric oxide has been shown to increase oxidative metabolism, improve fatigue resistance and endurance capacity, reduce resting blood pressure, and reduce oxygen cost during moderate intensity exercise (Handschin, 2016).
Why Cellular Optimizer™? Subramanian and Gupta (2015) explained how an increased consumption of leafy vegetables may not be enough to produce significant levels of NO3- and NO2- in the blood, or to result in clinical benefits. To support this claim, in a recent clinical study with older adults, plasma NO3- and NO2- were increased by a high NO3- supplement, but not by high NO3- foods.
PQQ as PureQQ™ (pyrroloquinoline quinone disodium salt)
Pyrroloquinoline Quinone (PQQ) is an antioxidant, supporting cardiovascular and cognitive function, as well as increasing energy production. It has been shown to fight reactive oxygen species, regulate cell signaling, and balance redox reactions (Nascent Health Sciences, 2013).
PQQ is also important for mitochondrial production and protection. To this point, the research of Chowanadisai et al. (2009) indicates potential benefits of PQQ in diseases associated with mitochondrial dysfunction. Mitochondrial biogenesis, which leads to an increase in energy, has been shown to increase longevity, improve energy utility, and protect against reactive oxygen species. If mitochondrial biogenesis is not functioning properly, or if there is a depletion or mutation in mitochondrial DNA, cardiomyopathy may develop. Additionally, conditions such as lactic acidosis, developmental delay, failure to thrive, and/or impaired neurological function could result from dysfunctional mitochondrial biogenesis (Chowanadisai et al., 2009).
PQQ has been found to play a beneficial role in nerve regeneration and repair. It has been shown to stimulate Nerve Growth Factor (NGF) production, as well as improve attention, information identification, and processing abilities. Koikeda, Nakano, and Masuda (2011) found that diets deficient in PQQ, can lead to impaired memory, learning, and other brain functions. The positive effects of PQQ on cognitive function has even led to further research on PQQ and its role in Parkinson's Disease (Nascent Health Sciences, 2013).
Jia et al. (2015) found that PQQ is also important for reducing oxidative stress, which is associated with fibrogenesis of the liver. Liver fibrosis can lead to cirrhosis, liver failure, and portal hypertension. PQQ acts as an anti-fibrotic agent and a reactive oxygen species scavenger, and resultantly suppresses oxidative stress.
Nakano et al. (2009) studied the efficacy and safety of PQQ, administered alone or in combination with CoQ10, and showed no adverse side effects. Studies have also been done on PQQ toxicity and Nakano et al. (2009) found no toxicity among participants ingesting 60 mg/day for a 4-week period.
PQQ is a friend to our body – particularly to our brain, vasculature, and liver. Not only can PQQ reduce oxidative stress, but it also can regulate cell signaling and balance redox reactions. Although PQQ is present in a variety of foods, the amounts of PQQ is minimal. Therefore, supplementation can help to meet the Nascent Heath Sciences (2013) recommended daily intake of PQQ for adults, which is 0.3 mg of PQQ/kg body weight/day (Nascent Health Sciences, 2013).
Coenzyme Q10 as H2Q (Hydro Q-Sorb™ CoQ10)
Interestingly, PQQ has enhanced effects with the addition of CoQ10 supplementation (Koikeda, Nakano, and Masuda, 2011). Coenzyme Q10 is a vitamin-like antioxidant nutrient naturally found in every cell in our body. It is necessary for the production of cellular energy, which is essential for every single process of life. Ubiquinol is the active, antioxidant, form of Coenzyme Q10. It shuttles and delivers electrons to oxygen to assist in energy production.
H2Q is an advanced bioavailability water miscible CoQ10 from the makers of Q-Gel, that uses pure Hydro-Q-Sorb™ CoQ10, a bioenhanced Coenzyme CoQ10, for enhanced dissolution and easier absorption.
It utilizes the advanced gamma cyclodextrin delivery system to promote absorption up to 8 times over standard CoQ10. Gamma cyclodextrin microencapsulates the CoQ10 molecule, assisting in its absorption through the small intestines, and releasing the CoQ10 into the bloodstream where cellular uptake occurs.
CoQ10 can be beneficial in those with mitochondrial disease, or in those who are chronically fatigued, over the age of 40, or exercise often. CoQ10, as an ATP energy trigger, has been shown to promote cardiovascular, liver, and kidney health, due to these organ’s high energy demands.
Furthermore, numerous scientific studies have indicated the need for CoQ10-containing supplements for prevention and successful treatment of disorders associated with the gums, or other supporting structures of the teeth. An adequate supply of CoQ10 ensures efficient energy production and tissue oxygenation for the healing and repair of periodontal tissue. Periodontal disease is the major cause of adult tooth loss, affecting 60% of young adults and 90% of individuals over the age of 65.
Research studies have shown that the gingival tissue, in a majority of patients with periodontal disease, is deficient in CoQ10. To this point, further research has demonstrated the "extraordinary" healing power of CoQ10 supplements in respect to periodontal disease. Health experts believe that CoQ10 supplementation can be used for the treatment of periodontitis, by itself, or in combination with traditional non-surgical periodontal therapy.
L-Arginine HCl (82.6% L-Arginine)
L-Arginine is involved in several processes such as protein synthesis and insulin secretion (Escudero et al., 2013). Furthermore, dietary supplements with L-arginine enhance intestinal integrity, improve vascular development, intestinal growth, and motility. In addition, the importance of L-arginine is attributed to its role as a precursor in the synthesis of nitric oxide by the three isoforms of nitric oxide synthase (Velickovic et al., 2014). Results of the research conducted by Velickovic et al. (2014) shows that long-term dietary L-arginine supplementation increases nitric oxide synthase, especially endothelial nitric oxide synthase (eNOS).
Epicatechin as PhytoSure™ (Wild Acacia catechu (L.F.) Bark/Leaf)
Epicatechin boosts tissue vascularization by activating nitric oxide signaling, resulting in higher levels of the vascular endothelial growth factor (Handschin, 2016).
Researchers investigated the safety and bioavailability of epicatechin supplementation, and found it to be well tolerated, safe with no adverse effects, and readily absorbed. Findings indicate increases in nitric oxide metabolites, mitochondrial enzyme function, and plasma follistatin levels, which may promote the beneficial effects of Epicatechin.
The research findings of these researchers suggest that epicatechin treatment combined with 8 weeks of endurance training provide a cumulative effect on angiogenic and mitochondrial signaling which functionally translates to enhanced exercise tolerance.
Epicatechin can be used to treat ischemic cardiac injury, neurodegeneration, diabetes, and cancer. Several signaling pathways have been implicated including nuclear factor erythroid 2p45 related factor 2, which regulates proliferation and redox balance, respectively.
Epicatechin intake has also been shown to have an inverse relationship to Coronary Heart Disease (CHD) mortality in elderly men and to Cardiovascular Disease mortality in prevalent cases of CVD.
In addition to other pulmonary arterial hypertension therapies, Archer et al. 2010 found epicatechin to be a suitable alternative to treat pulmonary arterial hypertension (PAH), as well as to improve upon mitochondrial abnormalities, like those observed in patients with PAH.