Sytrinol™ - A Natural Solution for Addressing Cholesterol

By Richard F. Staack, Ph.D., M.B.A.

Sytrinol™, a patented proprietary formula derived from natural citrus and palm fruit extracts, combines citrus polymethoxylated flavones (PMFs), palm tocotrienols and other proprietary constituents. This combination results in a synergistic effect for maintaining cholesterol levels in the normal range, including total cholesterol, LDL cholesterol, and triglyceride levels, as demonstrated by a long-term, three phase clinical trial.

This trial is extremely significant because it is a randomized, placebo-controlled, crossover design, one of only a few in the dietary supplement industry. Sytrinol has also been shown to maintain normal levels of high density lipoproteins (HDL), the beneficial cholesterol. Additionally, Sytrinol is a powerful antioxidant with numerous heart health benefits and also plays a significant role in reducing cellular irritation.

What are polymethoxylated flavones?

Polymethoxylated flavones are a highly methoxylated sub-classification of citrus flavonoids. This process occurs naturally and results in a more biologically active molecule. This is especially true for tangeretin and nobiletin, two of the primary polymethoxylated flavones in Sytrinol. Tocotrienols, naturally occurring analogues of tocopherol (natural vitamin E), are the other proprietary ingredient in Sytrinol and are a group of minor dietary constituents that have been studied for their effect on heart health.

Sytrinol's Proven Benefits

Sytrinol is the result of over 12 years of research focusing on the relationship between polymethoxylated flavonoids, tocotrienols, and cardiovascular health. Sytrinol's benefits have been shown in vitro, in vivo, and in multiple clinical studies. In these studies, subjects consumed 150 mg of Sytrinol twice per day (300 mg/day) and were instructed to keep the same dietary habits and maintain their caloric intake. Fasting blood samples were drawn at study onset, and at 4 weeks, 8 weeks, and 12 weeks. The results of the clinical studies were all similar in their effect, with a reduction of total cholesterol up to 30 percent, LDL cholesterol up to 27 percent, and total triglycerides up to 34 percent in twelve weeks compared to the placebo group. Additionally, the LDL/HDL ratio was significantly reduced in all clinical studies up to 30 percent.

Effect on C-reactive protein (CRP)

Another very important benefit of Sytrinol that cannot be claimed by other cholesterol-addressing supplements is its effect on C-reactive protein (CRP), which plays a role in cardiovascular challenges. Recent research has established that inflammation may cause C-reactive protein to be produced in the body. Specific PMFs, including nobiletin and tangeretin, have been studied for their anti-inflammatory properties, suggesting that Sytrinol may have a positive effect on CRP.

Antioxidant Benefit

Sytrinol has also been shown to be a powerful antioxidant. The polymethoxylated flavones have been researched for over 25 years demonstrating their antioxidant effects for heart health. Studies have shown that polymethoxylated flavonoids and their metabolites are excellent sources of dietary antioxidants that are able to suppress many of the events of free radical damage, including cellular irritation. The tocotrienols in Sytrinol have a higher antioxidant activity than tocopherols. Alpha-tocotrienol has been shown to be up to 60 times more potent than alpha-tocopherol in the prevention of lipid peroxidation. Other research has demonstrated that the delta and gamma isomers of tocotrienols also have potent antioxidant activity.

Mechanisms

Sytrinol has three complementary mechanisms of action in the body that deliver cardiovascular benefits.

Polymethoxylated flavones decrease apolipoprotein B, the structural protein needed for endogenous synthesis of LDL cholesterol.

Polymethoxylated flavones (tangeretin & nobiletin) decrease diacylglycerol acetyl transferase, a liver enzyme needed for endogenous synthesis of triglycerides.

Tocotrienols inhibit HMG CoA reductase, the liver enzyme responsible for endogenous synthesis of cholesterol.

These mechanisms work synergistically to support normal total cholesterol, LDL cholesterol, and triglyceride levels, more significantly than other natural supplements on the market today.

Sytrinol can also be combined with other ingredients such as phytosterols. Phytosterols help block cholesterol in the gastrointestinal tract while Sytrinol helps block cholesterol synthesis in the body. This suggests that, when combined, a more pronounced effect on maintaining normal cholesterol levels would result.

Consumer Friendly

The ease of compliance for consumers is a major consideration for a successful natural heart health product. Consumers do not have to take Sytrinol prior to, immediately following, or directly with their meals and, as a result, are more likely to take the correct dosage and continue using the product. Sytrinol can be taken in tablets, or softgels, which are easy to swallow because of the low dosage. Sytrinol will also be available in functional foods.

Acknowledgements

Dr. Richard Staack is the Vice President of Business Development, Technology, and Science at SourceOne™ Global Partners. He received his Master of Science and Doctorate in Nutritional and Biochemical Toxicology from the University of Illinois, Urbana-Champaign. He received his Master of Business Administration with Distinction from DeVry University. Dr Staack has received several awards and honors in the field of nutrition, is associated with numerous professional affiliations, and has published several articles on nutrition and toxicology in peer-reviewed journals.