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Topical Hyaluronic Acid Speeds Burn Healing Time

Department of Plastic and Reconstructive Surgery, Centre Hospitalier Universitaire, Toulouse Rangueil, France.

AIMS: This multicenter, multinational, randomized, double-blind, controlled, parallel-group study, was designed to assess the efficacy and safety of a fixed combination topical medicinal product, containing 0.2% hyaluronic acid and 1% silver sulfadiazine (HA-SSD) (Connettivina Plus cream) versus 1% silver sulfadiazine cream alone (SSD), in the treatment of second-degree burns.

METHODS: 111 adult patients (age 18-75 years) of both sexes, with IIa-degree (superficial) and IIb-degree (deep dermal) burns, were randomized to receive Hyaluronic Acid-SSD or SSD alone. Treatments (approximately 5 g/100 cm2) were applied once a day until the wounds healed, but for no longer than 4 weeks. Burns had to have occurred within 48 hours from the start of treatment, be caused by thermal injury, and be confined to the trunk and/or upper and lower extremities.

RESULTS: Results showed that both the fixed combination Hyaluronic Acid-SSD, and SSD alone, were effective and well tolerated topical agents for the treatment of second-degree burns. All burns were healed except in one patient treated with SSD. It was also observed that the fixed combination Hyaluronic Acid-SSD caused a significantly more rapid re-epithelialization of burns, i.e. a shorter time to healing, than SSD alone. The difference recorded--4.5 days--was statistically significant (p = 0.0073).

CONCLUSION: The observed shorter time to healing caused by the fixed combination is clinically relevant and further demonstrates the wound healing activity of Hyaluronic Acid.


Costagliola M, Agrosi M. Second-degree burns: a comparative, multicenter, randomized trial of hyaluronic acid plus silver sulfadiazine vs. silver sulfadiazine alone. Curr Med Res Opin. 2005 Aug;21(8):1235-40

Key concepts: hyaluronic acid, burns